Contwoyto Lake is a large lake in northwestern Nunavut. Descriptions of it say that its primary outlet leads to Bathurst Inlet.
Does the lake also have an outlet that leads to Chantrey Inlet, reaching the sea 300 miles to the east?
According to "Evaporation from a Small Lake in the Continental Arctic using Multiple Methods" Nordic Hydrology, 27, 1996, 1-24:
Drainage from Contwoyto Lake occurs through the Burnside River and Back River
So, yes, to Bathurst Inlet via the Burnside River and to Chantrey Inlet via the Back River.
You can trace out the two paths on the following topo map: http://en-ca.topographic-map.com/places/Contwoyto-Lake-947046/
The Back River outlet is at the south end of the lake and flows through a series of smaller lakes.